PostDoc x2 l Trypanosoma l Lisbon, PT Lisboa

PostDoc x2 l Trypanosoma l Lisbon, PT
Lisboa
Lisboa, Lisboa, Portugal

French Alliance for Parasitology and Health Care

Published: 14 January 2025

Overview

Two Post
Doc positions on Trypanosoma brucei and its interactions with blood vessels, Lisbon, Portugal

A collaborative project in the Lisbon area, Portugal, to explore groundbreaking interactions between Trypanosoma brucei and blood vessels. This parasite crosses blood vessels to invade critical organs like adipose tissue and the brain, complicating treatment and exacerbating disease outcomes. Our project, a collaborative endeavour between the Luisa Figueiredo Lab (GIMM, Lisbon) and the Claudio Franco Lab (CBR, Oeiras), seeks to unravel the molecular and cellular interactions between Trypanosoma brucei and endothelial cells during parasite crossing. Insights from this research could pave the way for novel treatment strategies not only for trypanosomiasis but also for related inflammatory and oncological conditions.

Projects

1. Position 1 – L. FIGUEIREDO Lab (GIMM, Lisbon) Focus: Characterizing parasite features essential for the crossing of blood vessels. Techniques: The successful candidate will employ a suite of
   - edge tools, including parasite genetics, in vitro crossing assays, genomic analysis, bioinformatics, cell sorting, advanced microscopy, and mouse infection models.
2. Position 2 – C. FRANCO Lab (CBR, Oeiras) Focus: Investigating endothelial cell phenotypes during parasite crossing at the
   - cell level. Techniques: This role will utilize
   - cell RNAseq,
   - resolution and live imaging microscopy, mouse genetic manipulation, and in vitro assays to provide insights into vascular dynamics during infection.

Prerequisites

Two independent yet collaborative thinkers with a passion for solving complex biological puzzles. Candidates should possess a doctoral degree in life sciences and have a strong background in molecular biology, cell culture, bioinformatics, or imaging techniques.

Application

Submit a CV, a statement of research interests, and two reference contacts to positions@gimm. pt, indicating the reference Cross
Tryp. Applications will be reviewed on a rolling basis until positions are filled.